N-methyl-2-pyrrolidinone
(NMP)
CH
5
H
9
NO
99.13 202 -24 1.033
Miscible
32 91
nitromethane
CH
3
NO
2
61.04 101.2 -29 1.382 9.50 35.9 35
pentane
C
5
H
12
72.15 36.1 -129.7 0.626 0.04 1.84 -49
petroleum ether (ligroine) -- -- 30-60 -40 0.656 -- -- -30
1-propanol
C
3
H
8
O
60.10 97 -126 0.803 Miscible 20.1(25) 22
2-propanol
C
3
H
8
O
60.10 82.4 -88.5 0.785 Miscible 18.3(25) 12
pyridine
C
5
H
5
N
79.10 115.2 -41.6 0.982 Miscible 12.3(25) 17
tetrahydrofuran (THF)
C
4
H
8
O
72.106 65 -108.4 0.8833 soluble² 7.52 -14
toluene
C
7
H
8
92.14 110.6 -93 0.867 0.05 2.38(25) 4
triethyl amine
C
6
H
15
N
101.19 88.9 -114.7 0.728 0.02 2.4 -11
water
H
2
O
18.02 100.00 0.00 0.998 -- 78.54 --
water, heavy
D
2
O
20.03 101.3 4 1.107 Miscible ?? --
o-xylene
C
8
H
10
106.17 144 -25.2 0.897 Insoluble 2.57 32
m-xylene
C
8
H
10
106.17 139.1 -47.8 0.868 Insoluble 2.37 27
p-xylene
C
8
H
10
106.17 138.4 13.3 0.861 Insoluble 2.27 27
Notes:
1. In 2005, this table was adapted by Dr. Brian J. Myers, Webmaster of ACS Division of Organic Division (DOC)
from: Professor Murov's Organic solvent table. The values were obtained from the CRC (87th edition), or Vogel's
Practical Organic Chemistry (5th ed.).
2. Solubilities are in water and are reported as grams solvent/100 grams water. The water solubility of THF is
complex. See: Pubchem
3. T = 20 °C unless specified otherwise.
4. You can find more detailed information (Health & Safety, Physical, Regulatory, Environmental) on various
organic solvents from Pubchem
5. Solvent guides for following Green Chemistry principles are available at:
https://organicchemistrydata.org/gcipr/
6. In 2020, Dr. Joseph Ward, DOC Head Webmaster formated the table to accommodate a wide range of screens and
add sorting to the table. Additionally, it was moved to the DOC's Organic Chemistry Data Website that was
created by Dr. Khoi Van.
7. A PDF version of this page is available here.
8. Question or comments? Contact the ACS Organic Division
9. This page was updated (table sorting was added): August 9, 2020. Methylene chloride F.P. and DMSO and NMP
Water solubility corrected October 2021.
10. © 2022 ACS Division of Organic Chemistry