Ponemah™ Analysis Modules

DSI is a pioneering biomedical research company focused on preclinical

systems physiology and pharmacology. The recognized global leader in

physiologic monitoring, DSI offers telemetry, instrumentation, software

and services that facilitate accelerated, well-informed drug therapy and

development decisions.

DSI serves many industries including: Pharmaceuticals, Academia,

Contract Research Organizations, Biological and Chemical defense, the

Medical Device Industry, Government and Biotechnology companies. We

offer solutions that are tailored specifically to meet the unique research

needs of our customers.

Headquarters and North American Sales:

1-800-262-9687 (U.S.)

1-651-481-7400 (International)

sales@datasci.com

datasci.com

European Sales:

Tel: 31-13-5479356

europe-sales@datasci.com

Asia Pacific Sales:

Tel: 86-21-50793177

DSI-shanghai-Office@datasci.com

Better Data. Better Science.

About Data Sciences International

Ponemah

™

Analysis Modules

Start Studies Quickly with Help from

DSI Scientific Services

DSI can help you streamline your studies by providing

expertise you can trust. With our services, we can help

you meet your software validation GLP requirements,

achieve greater implanted telemetry success and

summarize data for confidence in your results.

Data Services

DSI will assist you with creating high quality, useable

reports that summarize your experimental data. The

reduction in time spent on data analysis and reporting

processes will provide you with more time to evaluate

the experimental results and plan your next logical

experiment.

 Analysis expertise include hemodynamics, seizure

detection, sleep scoring and ECG evaluation

 Comprehensive, useable results

 Customized report package

Validation Services

Our experienced team offers a customized program

to help save time and reduce costs associated with

software systems validation.

 Customized Validation Solutions Package (VSP) with

test scripts

 Industry experienced GLP validation specialists

ScientificServices@datasci.com

Ponemah Analysis Modules

Trusted by researchers worldwide to discover

new insights into their research applications.

Confidence

 Obtain accurate, consistent results via validated

algorithms developed from scientific and peer-

reviewed journals

 Verify analysis accuracy with real-time visual feedback

 Operate with full compliance within GLP environments

with the Ponemah Data Security Option (DSO)

Speed

 Efficiently refine results by re-analyzing data

segments or manually editing mark placement

 Automatically detect noise and eliminate it

from results

 On-demand switching between time-based averages

or beat-to-beat data, which automatically export to

Microsoft Excel

or Access

Versatility

 Easily configure modules to analyze various signal

types from any species

 Instantly switch between time-based average or

beat-to-beat data

 Solutions for all applications, including implantable

telemetry, jacketed telemetry and traditional

hardwired solutions

DSI is a pioneering biomedical research company focused on preclinical

systems physiology and pharmacology. The recognized global leader in

physiologic monitoring, DSI offers telemetry, instrumentation, software

and services that facilitate accelerated, well-informed drug therapy and

development decisions.

DSI serves many industries including: Pharmaceuticals, Academia,

Contract Research Organizations, Biological and Chemical defense, the

Medical Device Industry, Government and Biotechnology companies. We

offer solutions that are tailored specifically to meet the unique research

needs of our customers.

Headquarters and North American Sales:

1-800-262-9687 (U.S.)

1-651-481-7400 (International)

sales@datasci.com

datasci.com

European Sales:

Tel: 31-13-5479356

europe-sales@datasci.com

Asia Pacific Sales:

Tel: 86-21-50793177

DSI-shanghai-Office@datasci.com

Better Data. Better Science.

About Data Sciences International

Ponemah

™

Analysis Modules

Start Studies Quickly with Help from

DSI Scientific Services

DSI can help you streamline your studies by providing

expertise you can trust. With our services, we can help

you meet your software validation GLP requirements,

achieve greater implanted telemetry success and

summarize data for confidence in your results.

Data Services

DSI will assist you with creating high quality, useable

reports that summarize your experimental data. The

reduction in time spent on data analysis and reporting

processes will provide you with more time to evaluate

the experimental results and plan your next logical

experiment.

 Analysis expertise include hemodynamics, seizure

detection, sleep scoring and ECG evaluation

 Comprehensive, useable results

 Customized report package

Validation Services

Our experienced team offers a customized program

to help save time and reduce costs associated with

software systems validation.

 Customized Validation Solutions Package (VSP) with

test scripts

 Industry experienced GLP validation specialists

ScientificServices@datasci.com

Ponemah Analysis Modules

Trusted by researchers worldwide to discover

new insights into their research applications.

Confidence

 Obtain accurate, consistent results via validated

algorithms developed from scientific and peer-

reviewed journals

 Verify analysis accuracy with real-time visual feedback

 Operate with full compliance within GLP environments

with the Ponemah Data Security Option (DSO)

Speed

 Efficiently refine results by re-analyzing data

segments or manually editing mark placement

 Automatically detect noise and eliminate it

from results

 On-demand switching between time-based averages

or beat-to-beat data, which automatically export to

Microsoft Excel

or Access

Versatility

 Easily configure modules to analyze various signal

types from any species

 Instantly switch between time-based average or

beat-to-beat data

 Solutions for all applications, including implantable

telemetry, jacketed telemetry and traditional

hardwired solutions

ECG Pattern Recognition Option (ECG PRO)

Greatly reduce processing time using ECG PRO’s

template-based analysis as it allows the selection

of a template cardiac cycle for precise comparison

to other cycles in the dataset.

 Save time by only attempting to match unmatched

cycles or within specific regions

 Automatically adjust the ECG waveform’s cycle

marks based on the template(s)

Systemic Blood Flow (SBF)

Analyzes systemic blood flow from the circulatory

system and eliminates drift resulting from certain types

of flow meters.

• Mean • Flow Maximum • Flow Minimum • Cardiac Output

• Stroke Volume • +dQ • Iso Flow • Total Peripheral Resistance

• Non Pulsatile Mean

PV Loop

Permits the display and analysis of LVP cycles

plotted against cardiac volume cycles.

Characterization of End Systolic Pressure Volume Relationship,

End Diastolic Pressure Volume Relationship and Pre-Recruitable

Stroke Work

Raw Electrical Mean

Analyzes any type of input signal that has no specific

analysis module. This module comes with the Ponemah

application.

• Mean • Maximum • Minimum • Period • Beats per Minute

• Area • Total Activity • Non Pulsatile Mean

Pulmonary Volume (PVO)

Analyzes pulmonary volume signals to derive

respiratory endpoints obtained from respiratory

impedance transmitters (D70-PCTR).

• Peak Inspiratory Flow • Peak Expiratory Flow • Tidal Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Apnea Time • Penh • Relaxation Time

• Tidal Volume (Expiration) • Inspiratory/Expiratory Flow 50%

• Accumulated Volume • Volume Baseline • Volume Fluctuation

• Flow Fluctuation • Median Tidal Volume • Median Tidal Volume

xpired • Tidal Volume Throughout • Tidal Volume Expired

Throughout • PZr Ratio

Pulmonary Air Flow and Airway Resistance (PAF)

Analyzes any pulmonary signal derived from a

plethysmography chamber, pneumotach or Jacketed

External Telemetry (JET™) Respiratory impedance bands.

• Peak Inspiratory Flow • Peak Expiratory Flow • Title Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Apnea Time • Specific Airway Resistance

• Phase Shift • Delay Time • Penh • Relaxation Time • Tidal Volume

(

Expiration) • Accumulated Volume • Inspiratory/Expiratory Flow

50% • Ratio EF/IF 50% • Apneic Interval

Unrestrained Plethysmography (URP)

Analyzes signals obtained from unrestrained whole

body plethysmography chambers. Includes the ability to

compensate for environmental conditions to calculate

adjusted volumes.

• Peak Inspiratory Flow • Peak Expiratory Flow • Tidal Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Pause • Penh • TVadj • MVadj • Apnea Time

• Apnea Count • Inspiratory/Expiratory Flow 50% • Ratio EF/IF 50%

• A

pneic Interval

Pulmonary Compliance & Resistance (PCR/PCRP)

Analyzes pulmonary signals from either a

plethysmographic chamber or a pneumotachometer,

along with a pressure, in anesthetized or conscious

animal models.

• Peak Inspiratory Flow • Peak Expiratory Flow • Tidal Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Apnea Time • Resistance • Compliance

• Conductance • Multiple Resistances at Specified Points • Average

ompliance • Average Resistance • Pressures at Start of Inspiration/

Expiration • Flow and Pressure at Isovolumetric Points • Penh

• Relaxation Time • Work and Power of Breathing Calculations • Tidal

olume (Expiration) • Accumulated Volume • Inspiratory/Expiratory

Flow 50%

Diaphragmatic EMG (dEMG)

Analyzes diaphragmatic EMG signals to provide

respiratory endpoints.

• Respiration Rate • Tidal Volume* • Minute Ventilation*

• Inspiration Time • Expiration Time • Total Time

Tidal Volume and Minute Ventilation are only partial

representations as diaphragmatic activity is only a partial

representation of the respiratory mechanics.

Electromyogram (EMG)

Analyzes the electrical activity of muscle tissue.

• Integral • Peak

Action Potential (MAP)

Analyzes a host of action potentials with focus on

key regions such as plateau, recovery time and

upstroke velocity.

• Maximum • EDV • Minimum • Plateau • Amp • Rate • +dV

• -dV • Recovery 1 • xR1 • Recovery 2 • xR2 • Recovery 3 • xR3

• %Max • Time • Count • RiseT

Electroencephalogram (NeuroScore™)

DSI offers NeuroScore CNS analysis software for

sleep and seizure detection. NeuroScore is fully

compatible with the Ponemah system and can analyze

data collected by implantable telemetry, external

telemetry and hardwired amplifiers.

Cystometry (CYS)

Analyzes pressures resulting from non-voiding bladder

contraction cycles or longer time-scale pressure changes

resulting from bladder filling/voiding cycles.

• Peak Pressure • Base Pressure• Rise• Period • Peak Duration

• Inter-Contraction Interval • Duty Cycle • Time to Peak • Peak

ount • Peak Count Time • Area • Start Time • Peak Time • End

Time • Maximum Derivative • Minimum Derivative

Pulsatile Tissue and Gut Motility (PT)

Analyzes signals from isotonic or isometric transducers

from spontaneously or repetitively beating preparations.

• Maximum • Minimum • Average • Delta • Rate • Time to Peak

• +d_/dt • -d_/dt • %Recovery 1 • %Recovery 2 • +d’/dt • -d’/dt

• Motility Index • Area

NeuroScore

™

CNS Data Analysis Software

NeuroScore is a versatile, streamlined solution

that combines easy-to-use tools, efficient data

processing and accurate data analysis to reduce

time to results. Choose the CNS software modules

that best meet your research needs.

Sleep Scoring Modules

Dramatically reduce analysis time and variability using

the Rodent and Large Animal Sleep Scoring modules.

Automated Rodent Sleep Scoring

 Scoring based on the frequency content of the EEG

and presence of EMG activity and movement.

 Stages include: Paradoxical Sleep, Slow Wave Sleep

(SWS-1 and SWS-2), Wake and Active Wake.

Automated Large Animal Sleep Scoring

 Based on the American Academy of Sleep Medicine

standards for human sleep scoring, this algorithm

uses EEG, EMG, EOG and activity data.

 Stages include REM, Non-REM (N1, N2, N3), Wake,

and Active Wake.

Seizure Detection Module

The Spike Train detector scans the waveform

for repeating EEG spike activity via user-defined

amplitude-based criteria.

Several parameters including spike train duration

and number of spikes can be displayed per event

or summarized over longer time intervals.

Video Synchronization Module

Improve confidence in results by synchronizing video

data acquired with Dataquest A.R.T. or Ponemah to

validate or further classify detected events.

Batch Processing Module

Increase throughput by automating analysis processes

on multiple recordings at once. Customize workflows to:

 Score multiple recordings

 Export signal or parameter data

 Generate and export reports

 Complete these three steps within a single workflow

Multi-Lead Electrocardiogram (ECG)

Analyzes ECG signals to provide single and

multi-lead calculations.

• P, Q, S and T Wave Degree of Match using ECG PRO • Heart Rate

• R-R Interval • QT Interval • ST Interval • P-R Interval • QR Interval

• Q

RS Width • P Width • R, P and T Wave Heights • T Height Negative

• QR Amplitude • Variable ST Elevation • Q Alpha T Negative

• Multiple Corrected QT Calculations • QT Dispersion • +dV/dt Max

• T A

rea • P, T, QT and R Count • Bad, Good and Total Waves • T Peak

• T Peak Interval • Noise • Timing, Channel and Dispersion

Information Across Multiple Leads

Blood Pressure (BP)

Analyzes arterial and venous pressures.

• Systolic • Diastolic • Mean • Pulse Height • Heart Rate • Time to

Peak • Ejection Time • +dP/dt •-dP/dt • %Recovery • Non Pulsatile

Mean • Q-A Interval • Pulse Transit Time • Pulse Wave Velocity

• Inter-Beat Interval • Count

Blood Pressure Respiratory (BPR)

Derive respiration values from the cardiac cycle when

used in conjunction with the BP module.

• Respiration Rate • Interval

Left Ventricular Pressure (LVP)

Analyzes pressure signals from the left ventricle and

is used as a reference signal for other analysis modules,

such as Cardiac Volume.

• Systolic • LVEDP • Minimum Pressure • Time Tension Index

• Developed Pressure • Heart Rate • +dP/dt • -dP/dt • Contractility

ndex • Relaxation Times (1 & 2) • dP/dt at Selected Pressures

• Non Pulsatile Mean • Q-A Interval • IVT (Time from Systolic to

VEDP) • TTI-T (Time from LVEDP to –dP/dt) • Tau • Period

• Electromechanical Window • Count

Heart Rate Variability (HRV)

Analyzes the R-R intervals of ECG signals or

Inter-Beat-Intervals of blood pressure signals to convert

these time-based calculations to the frequency domain,

revealing the frequency components of the signals.

• Very Low Frequency (VLF) • Low Frequency (LF) • High Frequency

(HF) • Normalized LF and HF • LF/HF Ratio • Total Power

Cardiac Volume (CVOL)

Analyzes any volume from the circulatory system

and can derive values relative to the cardiac cycle.

• Heart Rate • Minimum Volume • Maximum Volume • Stroke

Volume • Volume at LVP Min Slope • Pressure at LVEDP • Volume

at LVEDP • Ejection Fraction • Peak Filling Rate • Peak Emptying

Rate • Time to Peak Filling Rate • Diastolic Filling Time • Time to

Peak Filling (Percentage) • Pressure at Max Elastance • Volume at

Max Elastance • Stroke Work • Arterial Elastance

Coronary Blood Flow (CBF)

Provides coronary flow and volume information

during systolic and diastolic periods in conjunction

with the LVP module.

• Mean • Flow Maximum • Flow Minimum • Cardiac Output • Stroke

Volume • +dQ • Systolic Flow • Diastolic Flow • Systolic Volume

• Diastolic Volume • -Flow • Total Volume • Non Pulsatile Mean

Automated validation marks for Q, R, S, End of T and Beginning

of P are shown. The validation marks provide visual, online

verification of the accuracy of the system.

Ponemah High Performance Analysis Modules

ECG PRO template library graph.

Mouse over cycle match. Can get visual information for each

cycle (how well it matched and to what template) by mousing

over the complex.

NeuroScore Workspace view for Sleep Scoring with Video Player.

 Multiple templates can be used in a dataset and

templates can be added to a template library

for use in other studies

 Accelerates the process of locating potential

arrhythmic beats

ECG Pattern Recognition Option (ECG PRO)

Greatly reduce processing time using ECG PRO’s

template-based analysis as it allows the selection

of a template cardiac cycle for precise comparison

to other cycles in the dataset.

 Save time by only attempting to match unmatched

cycles or within specific regions

 Automatically adjust the ECG waveform’s cycle

marks based on the template(s)

Systemic Blood Flow (SBF)

Analyzes systemic blood flow from the circulatory

system and eliminates drift resulting from certain types

of flow meters.

• Mean • Flow Maximum • Flow Minimum • Cardiac Output

• Stroke Volume • +dQ • Iso Flow • Total Peripheral Resistance

• Non Pulsatile Mean

PV Loop

Permits the display and analysis of LVP cycles

plotted against cardiac volume cycles.

Characterization of End Systolic Pressure Volume Relationship,

End Diastolic Pressure Volume Relationship and Pre-Recruitable

Stroke Work

Raw Electrical Mean

Analyzes any type of input signal that has no specific

analysis module. This module comes with the Ponemah

application.

• Mean • Maximum • Minimum • Period • Beats per Minute

• Area • Total Activity • Non Pulsatile Mean

Pulmonary Volume (PVO)

Analyzes pulmonary volume signals to derive

respiratory endpoints obtained from respiratory

impedance transmitters (D70-PCTR).

• Peak Inspiratory Flow • Peak Expiratory Flow • Tidal Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Apnea Time • Penh • Relaxation Time

• Tidal Volume (Expiration) • Inspiratory/Expiratory Flow 50%

• Accumulated Volume • Volume Baseline • Volume Fluctuation

• Flow Fluctuation • Median Tidal Volume • Median Tidal Volume

xpired • Tidal Volume Throughout • Tidal Volume Expired

Throughout • PZr Ratio

Pulmonary Air Flow and Airway Resistance (PAF)

Analyzes any pulmonary signal derived from a

plethysmography chamber, pneumotach or Jacketed

External Telemetry (JET™) Respiratory impedance bands.

• Peak Inspiratory Flow • Peak Expiratory Flow • Title Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Apnea Time • Specific Airway Resistance

• Phase Shift • Delay Time • Penh • Relaxation Time • Tidal Volume

(

Expiration) • Accumulated Volume • Inspiratory/Expiratory Flow

50% • Ratio EF/IF 50% • Apneic Interval

Unrestrained Plethysmography (URP)

Analyzes signals obtained from unrestrained whole

body plethysmography chambers. Includes the ability to

compensate for environmental conditions to calculate

adjusted volumes.

• Peak Inspiratory Flow • Peak Expiratory Flow • Tidal Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Pause • Penh • TVadj • MVadj • Apnea Time

• Apnea Count • Inspiratory/Expiratory Flow 50% • Ratio EF/IF 50%

• A

pneic Interval

Pulmonary Compliance & Resistance (PCR/PCRP)

Analyzes pulmonary signals from either a

plethysmographic chamber or a pneumotachometer,

along with a pressure, in anesthetized or conscious

animal models.

• Peak Inspiratory Flow • Peak Expiratory Flow • Tidal Volume

• Minute Volume • Respiration Rate • Inspiratory Time • Expiratory

ime • Total Time • Apnea Time • Resistance • Compliance

• Conductance • Multiple Resistances at Specified Points • Average

ompliance • Average Resistance • Pressures at Start of Inspiration/

Expiration • Flow and Pressure at Isovolumetric Points • Penh

• Relaxation Time • Work and Power of Breathing Calculations • Tidal

olume (Expiration) • Accumulated Volume • Inspiratory/Expiratory

Flow 50%

Diaphragmatic EMG (dEMG)

Analyzes diaphragmatic EMG signals to provide

respiratory endpoints.

• Respiration Rate • Tidal Volume* • Minute Ventilation*

• Inspiration Time • Expiration Time • Total Time

Tidal Volume and Minute Ventilation are only partial

representations as diaphragmatic activity is only a partial

representation of the respiratory mechanics.

Electromyogram (EMG)

Analyzes the electrical activity of muscle tissue.

• Integral • Peak

Action Potential (MAP)

Analyzes a host of action potentials with focus on

key regions such as plateau, recovery time and

upstroke velocity.

• Maximum • EDV • Minimum • Plateau • Amp • Rate • +dV

• -dV • Recovery 1 • xR1 • Recovery 2 • xR2 • Recovery 3 • xR3

• %Max • Time • Count • RiseT

Electroencephalogram (NeuroScore™)

DSI offers NeuroScore CNS analysis software for

sleep and seizure detection. NeuroScore is fully

compatible with the Ponemah system and can analyze

data collected by implantable telemetry, external

telemetry and hardwired amplifiers.

Cystometry (CYS)

Analyzes pressures resulting from non-voiding bladder

contraction cycles or longer time-scale pressure changes

resulting from bladder filling/voiding cycles.

• Peak Pressure • Base Pressure• Rise• Period • Peak Duration

• Inter-Contraction Interval • Duty Cycle • Time to Peak • Peak

ount • Peak Count Time • Area • Start Time • Peak Time • End

Time • Maximum Derivative • Minimum Derivative

Pulsatile Tissue and Gut Motility (PT)

Analyzes signals from isotonic or isometric transducers

from spontaneously or repetitively beating preparations.

• Maximum • Minimum • Average • Delta • Rate • Time to Peak

• +d_/dt • -d_/dt • %Recovery 1 • %Recovery 2 • +d’/dt • -d’/dt

• Motility Index • Area

NeuroScore

™

CNS Data Analysis Software

NeuroScore is a versatile, streamlined solution

that combines easy-to-use tools, efficient data

processing and accurate data analysis to reduce

time to results. Choose the CNS software modules

that best meet your research needs.

Sleep Scoring Modules

Dramatically reduce analysis time and variability using

the Rodent and Large Animal Sleep Scoring modules.

Automated Rodent Sleep Scoring

 Scoring based on the frequency content of the EEG

and presence of EMG activity and movement.

 Stages include: Paradoxical Sleep, Slow Wave Sleep

(SWS-1 and SWS-2), Wake and Active Wake.

Automated Large Animal Sleep Scoring

 Based on the American Academy of Sleep Medicine

standards for human sleep scoring, this algorithm

uses EEG, EMG, EOG and activity data.

 Stages include REM, Non-REM (N1, N2, N3), Wake,

and Active Wake.

Seizure Detection Module

The Spike Train detector scans the waveform

for repeating EEG spike activity via user-defined

amplitude-based criteria.

Several parameters including spike train duration

and number of spikes can be displayed per event

or summarized over longer time intervals.

Video Synchronization Module

Improve confidence in results by synchronizing video

data acquired with Dataquest A.R.T. or Ponemah to

validate or further classify detected events.

Batch Processing Module

Increase throughput by automating analysis processes

on multiple recordings at once. Customize workflows to:

 Score multiple recordings

 Export signal or parameter data

 Generate and export reports

 Complete these three steps within a single workflow

Multi-Lead Electrocardiogram (ECG)

Analyzes ECG signals to provide single and

multi-lead calculations.

• P, Q, S and T Wave Degree of Match using ECG PRO • Heart Rate

• R-R Interval • QT Interval • ST Interval • P-R Interval • QR Interval

• Q

RS Width • P Width • R, P and T Wave Heights • T Height Negative

• QR Amplitude • Variable ST Elevation • Q Alpha T Negative

• Multiple Corrected QT Calculations • QT Dispersion • +dV/dt Max

• T A

rea • P, T, QT and R Count • Bad, Good and Total Waves • T Peak

• T Peak Interval • Noise • Timing, Channel and Dispersion

Information Across Multiple Leads

Blood Pressure (BP)

Analyzes arterial and venous pressures.

• Systolic • Diastolic • Mean • Pulse Height • Heart Rate • Time to

Peak • Ejection Time • +dP/dt •-dP/dt • %Recovery • Non Pulsatile

Mean • Q-A Interval • Pulse Transit Time • Pulse Wave Velocity

• Inter-Beat Interval • Count

Blood Pressure Respiratory (BPR)

Derive respiration values from the cardiac cycle when

used in conjunction with the BP module.

• Respiration Rate • Interval

Left Ventricular Pressure (LVP)

Analyzes pressure signals from the left ventricle and

is used as a reference signal for other analysis modules,

such as Cardiac Volume.

• Systolic • LVEDP • Minimum Pressure • Time Tension Index

• Developed Pressure • Heart Rate • +dP/dt • -dP/dt • Contractility

ndex • Relaxation Times (1 & 2) • dP/dt at Selected Pressures

• Non Pulsatile Mean • Q-A Interval • IVT (Time from Systolic to

VEDP) • TTI-T (Time from LVEDP to –dP/dt) • Tau • Period

• Electromechanical Window • Count

Heart Rate Variability (HRV)

Analyzes the R-R intervals of ECG signals or

Inter-Beat-Intervals of blood pressure signals to convert

these time-based calculations to the frequency domain,

revealing the frequency components of the signals.

• Very Low Frequency (VLF) • Low Frequency (LF) • High Frequency

(HF) • Normalized LF and HF • LF/HF Ratio • Total Power

Cardiac Volume (CVOL)

Analyzes any volume from the circulatory system

and can derive values relative to the cardiac cycle.

• Heart Rate • Minimum Volume • Maximum Volume • Stroke

Volume • Volume at LVP Min Slope • Pressure at LVEDP • Volume

at LVEDP • Ejection Fraction • Peak Filling Rate • Peak Emptying

Rate • Time to Peak Filling Rate • Diastolic Filling Time • Time to

Peak Filling (Percentage) • Pressure at Max Elastance • Volume at

Max Elastance • Stroke Work • Arterial Elastance

Coronary Blood Flow (CBF)

Provides coronary flow and volume information

during systolic and diastolic periods in conjunction

with the LVP module.

• Mean • Flow Maximum • Flow Minimum • Cardiac Output • Stroke

Volume • +dQ • Systolic Flow • Diastolic Flow • Systolic Volume

• Diastolic Volume • -Flow • Total Volume • Non Pulsatile Mean

Automated validation marks for Q, R, S, End of T and Beginning

of P are shown. The validation marks provide visual, online

verification of the accuracy of the system.

Ponemah High Performance Analysis Modules

ECG PRO template library graph.

Mouse over cycle match. Can get visual information for each

cycle (how well it matched and to what template) by mousing

over the complex.

NeuroScore Workspace view for Sleep Scoring with Video Player.

 Multiple templates can be used in a dataset and

templates can be added to a template library

for use in other studies

 Accelerates the process of locating potential

arrhythmic beats

DSI is a pioneering biomedical research company focused on preclinical

systems physiology and pharmacology. The recognized global leader in

physiologic monitoring, DSI offers telemetry, instrumentation, software

and services that facilitate accelerated, well-informed drug therapy and

development decisions.

DSI serves many industries including: Pharmaceuticals, Academia,

Contract Research Organizations, Biological and Chemical defense, the

Medical Device Industry, Government and Biotechnology companies. We

offer solutions that are tailored specifically to meet the unique research

needs of our customers.

Headquarters and North American Sales:

1-800-262-9687 (U.S.)

1-651-481-7400 (International)

sales@datasci.com

datasci.com

European Sales:

Tel: 31-13-5479356

europe-sales@datasci.com

Asia Pacific Sales:

Tel: 86-21-50793177

DSI-shanghai-Office@datasci.com

Better Data. Better Science.

About Data Sciences International

Ponemah

™

Analysis Modules

Start Studies Quickly with Help from

DSI Scientific Services

DSI can help you streamline your studies by providing

expertise you can trust. With our services, we can help

you meet your software validation GLP requirements,

achieve greater implanted telemetry success and

summarize data for confidence in your results.

Data Services

DSI will assist you with creating high quality, useable

reports that summarize your experimental data. The

reduction in time spent on data analysis and reporting

processes will provide you with more time to evaluate

the experimental results and plan your next logical

experiment.

 Analysis expertise include hemodynamics, seizure

detection, sleep scoring and ECG evaluation

 Comprehensive, useable results

 Customized report package

Validation Services

Our experienced team offers a customized program

to help save time and reduce costs associated with

software systems validation.

 Customized Validation Solutions Package (VSP) with

test scripts

 Industry experienced GLP validation specialists

ScientificServices@datasci.com

Ponemah Analysis Modules

Trusted by researchers worldwide to discover

new insights into their research applications.

Confidence

 Obtain accurate, consistent results via validated

algorithms developed from scientific and peer-

reviewed journals

 Verify analysis accuracy with real-time visual feedback

 Operate with full compliance within GLP environments

with the Ponemah Data Security Option (DSO)

Speed

 Efficiently refine results by re-analyzing data

segments or manually editing mark placement

 Automatically detect noise and eliminate it

from results

 On-demand switching between time-based averages

or beat-to-beat data, which automatically export to

Microsoft Excel

or Access

Versatility

 Easily configure modules to analyze various signal

types from any species

 Instantly switch between time-based average or

beat-to-beat data

 Solutions for all applications, including implantable

telemetry, jacketed telemetry and traditional

hardwired solutions

DSI is a pioneering biomedical research company focused on preclinical

systems physiology and pharmacology. The recognized global leader in

physiologic monitoring, DSI offers telemetry, instrumentation, software

and services that facilitate accelerated, well-informed drug therapy and

development decisions.

DSI serves many industries including: Pharmaceuticals, Academia,

Contract Research Organizations, Biological and Chemical defense, the

Medical Device Industry, Government and Biotechnology companies. We

offer solutions that are tailored specifically to meet the unique research

needs of our customers.

Headquarters and North American Sales:

1-800-262-9687 (U.S.)

1-651-481-7400 (International)

sales@datasci.com

datasci.com

European Sales:

Tel: 31-13-5479356

europe-sales@datasci.com

Asia Pacific Sales:

Tel: 86-21-50793177

DSI-shanghai-Office@datasci.com

Better Data. Better Science.

About Data Sciences International

Ponemah

™

Analysis Modules

Start Studies Quickly with Help from

DSI Scientific Services

DSI can help you streamline your studies by providing

expertise you can trust. With our services, we can help

you meet your software validation GLP requirements,

achieve greater implanted telemetry success and

summarize data for confidence in your results.

Data Services

DSI will assist you with creating high quality, useable

reports that summarize your experimental data. The

reduction in time spent on data analysis and reporting

processes will provide you with more time to evaluate

the experimental results and plan your next logical

experiment.

 Analysis expertise include hemodynamics, seizure

detection, sleep scoring and ECG evaluation

 Comprehensive, useable results

 Customized report package

Validation Services

Our experienced team offers a customized program

to help save time and reduce costs associated with

software systems validation.

 Customized Validation Solutions Package (VSP) with

test scripts

 Industry experienced GLP validation specialists

ScientificServices@datasci.com

Ponemah Analysis Modules

Trusted by researchers worldwide to discover

new insights into their research applications.

Confidence

 Obtain accurate, consistent results via validated

algorithms developed from scientific and peer-

reviewed journals

 Verify analysis accuracy with real-time visual feedback

 Operate with full compliance within GLP environments

with the Ponemah Data Security Option (DSO)

Speed

 Efficiently refine results by re-analyzing data

segments or manually editing mark placement

 Automatically detect noise and eliminate it

from results

 On-demand switching between time-based averages

or beat-to-beat data, which automatically export to

Microsoft Excel

or Access

Versatility

 Easily configure modules to analyze various signal

types from any species

 Instantly switch between time-based average or

beat-to-beat data

 Solutions for all applications, including implantable

telemetry, jacketed telemetry and traditional

hardwired solutions