7
May 2014 LA County Department of Public Health Rx for Prevention
Another health concern is the chronic inhalation of pro-
pylene glycol, the main ingredient in e-liquid. Even though
propylene glycol is FDA-approved for oral consumption, the
inhalation of vaporized nicotine in propylene glycol is not.
Short-term exposure causes eye, throat, and airway irrita-
tion, and long-term exposure can result in children develop-
ing asthma. Some studies show that heating propylene glycol
changes its chemical composition, producing small amounts
of propylene oxide, a known carcinogen.
Nicotine toxicity is a significant health concern, given
reports of accidental poisonings from e-cigarette products on
the rise, particularly among children. E-cigarette-related calls
to poison control centers tripled between 2012 and 2013, and
the number of poisonings jumped to 1,351 in 2013, a 300%
increase from 2012. The CDC reported a dramatic rise in the
number of e-cigarette-related phone calls to poison control
centers, from just 1 call per month on average in 2010 to
nearly 200 calls per month in early 2014. More than 50% of
the calls involved children aged 5 and under.
Signs of Nicotine Toxicity
Liquid nicotine is far more dangerous than that found in other
tobacco products because it is absorbed more quickly. Toxi-
cologists identify potential dangers of e-liquids because of
their neurotoxicity and ability to be lethally absorbed quickly
through the skin.
Health care providers should be familiar with signs and
symptoms related to nicotine toxicity. Mild symptoms include
nausea, vomiting, dizziness, drowsiness, increased heart rate,
and increased blood pressure. More severe symptoms include
seizures, decreased heart rate, and decreased blood pressure.
Symptoms from skin or eye exposure include irritation,
redness, severe pain, and inflammation, and may result in
whole-body toxicity.
Recommendations
Given the unknown public health impact and the current
lack of regulation, the Los Angeles County Department of
Public Health recommends a precautionary approach regard-
ing the use of e-cigarettes until further research is available.
The CDC, along with other health agencies, recommend that
health care providers consider the following actions:
• Be well-informed and vigilant that e-cigarettes have the
potential to cause acute adverse health effects and represent
an emerging public health concern.
• Inform patients of potential dangers of e-cigarettes and
encourage parents to talk to their children and to discour-
age use. Advise patients to keep e-cigarettes out of reach of
children, preferably locked in a secure place.
• Inform patients that e-cigarettes have not been approved by
the FDA as a quit-smoking aid. Encourage the use of FDA-
approved smoking-cessation medication among patients
who want to quit. Additional information on strategies and
support for quitting smoking can be found online at
www.LAQuits.com or by calling 1-800-NO-BUTTS.
Update
At press time, the FDA proposed rules to strictly regulate
electronic cigarettes, cigars, pipe tobacco, nicotine gels, water
pipe tobacco, and hookahs. After a 75-day public comment
period (starting April 25, 2014), the proposed rules include
the following:
• Setting the age limit to buy the products to be at least
18 years (states can set it higher)
• Health warnings required on all products
• Sale of the products in vending machines
would be prohibited
• Manufacturers would be required to register all of their
products and ingredients with the FDA
• Manufacturers would only be able to market new products
after an FDA review
• Manufacturers would need to provide scientic evidence
before making any claims of risk reduction tied to use of
their product.
Susan Bradshaw, MD, MPH, ABIHM, is a Physician Specialist, and
Tonya Gorham Gallow, MSW, is Director, Tobacco Control and Preven-
tion Program, Los Angeles County Department of Public Health.
REFERENCES
1. Tobacco Fact Sheet–Electronic Cigarettes (E-Cigarettes). (June
2013). American Legacy Foundation. Retrieved from: http://www.
legacyforhealth.org/content/download/ 582/6926/le/LEG-Fact-
Sheet-eCigarettes-JUNE2013.pdf.
2. Questions and answers on electronic cigarettes or electronic
nicotine delivery systems (ENDS). (July 2013). World Health Organi-
zation, Tobacco Free Initiative. Retrieved from: http://www.who.int/
tobacco/communications/statements/eletronic_cigarettes/en/.
3. E-Cigarettes [fact sheet]. (Oct 2013). American Academy of Pediat-
rics–Julius B. Richmond Center of Excellence. Retrieved from: http://
www2.aap.org/richmondcenter/ pdfs/ECigarette_handout.pdf.
4. Food and Drug Administration. News and events—electronic
cigarettes (e-cigarettes). Silver Spring, Maryland: US Department of
Health and Human Services, Food and Drug Administration; 2014.
Available at http://www.fda.gov/newsevents/publichealthfocus/
ucm172906.htm.
5. Herzog B.E- Cigs Revolutionizing The Tobacco Industry; Wells Far-
go Security Equity Research, June 12, 2013. (Email Correspondence).
6. Mangan D. “E-cigarette sales are smoking hot, set to hit
$1.7 billion.” CNBC. 28 August 2013. Available at: http://
www.cnbc.com/id/100991511.
7. Centers for Disease Control and Prevention. Morbidity and Mortal-
ity Weekly Report: Notes from the Field: Electronic Cigarette Use
Among Middle and High School Students – United States, 2011-
2012. MMWR 2013;62:p729-830.
8. Centers for Disease Control and Prevention. Press Release: About
one in ve U.S. adult cigarette smokers have tried an electronic
cigarette. CDC. 28 February 2013. Available at: http://www.cdc.gov/
media/releases/2013/ p0228_electronic_cigarettes.html.