SAFETY DATA SHEET

Creation Date 13-Oct-2009 Revision Date 13-Oct-2023 Revision Number 7

1. Identification

Product Name Ethyl acetate

Cat No. : E195-1; E195-4; E195N1-19; E195N2-19; E195RS-19; E195RS-50;

E195RS-115; E195RS-200; E195SK-1; E195SK-4; E195SK4004;

E195SK4005; E195SK4006; E195SS-19; E195SS-50; E195SS-115;

NC1308052; NC1899880

CAS No

141-78-6

Synonyms

Acetic acid ethyl ester

Recommended Use

Laboratory chemicals.

Uses advised against

Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

2. Hazard(s) identification

Classification

This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal Word

Danger

Hazard Statements

Highly flammable liquid and vapor

Company

Fisher Scientific Company

One Reagent Lane

Fair Lawn, NJ 07410

Tel: (201) 796-7100

Emergency Telephone Number

CHEMTRECÒ, Inside the USA: 800-424-9300

CHEMTRECÒ, Outside the USA: 001-703-527-3887

Serious Eye Damage/Eye Irritation Category 2

Specific target organ toxicity (single exposure) Category 3

Target Organs - Central nervous system (CNS).

Flammable liquids Category 2

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Ethyl acetate

Revision Date 13-Oct-2023

Causes serious eye irritation

May cause drowsiness or dizziness

Precautionary Statements

Prevention

Wash face, hands and any exposed skin thoroughly after handling

Do not breathe dust/fume/gas/mist/vapors/spray

Use only outdoors or in a well-ventilated area

Keep away from heat/sparks/open flames/hot surfaces. - No smoking

Keep container tightly closed

Ground/bond container and receiving equipment

Use explosion-proof electrical/ventilating/lighting equipment

Use only non-sparking tools

Take precautionary measures against static discharge

Wear protective gloves/protective clothing/eye protection/face protection

Keep cool

Response

Get medical attention/advice if you feel unwell

Inhalation

IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing

Call a POISON CENTER or doctor/physician if you feel unwell

Skin

IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower

Eyes

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

If eye irritation persists: Get medical advice/attention

Fire

In case of fire: Use CO2, dry chemical, or foam for extinction

Storage

Store in a well-ventilated place. Keep container tightly closed

Store locked up

Disposal

Dispose of contents/container to an approved waste disposal plant

Hazards not otherwise classified (HNOC)

Repeated exposure may cause skin dryness or cracking

3. Composition/Information on Ingredients

Component CAS No Weight %

Ethyl acetate 141-78-6 <=100

4. First-aid measures

General Advice

If symptoms persist, call a physician.

Eye Contact

Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get

medical attention.

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Ethyl acetate

Revision Date 13-Oct-2023

Skin Contact

Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,

call a physician.

Inhalation

Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if

symptoms occur.

Ingestion

Clean mouth with water and drink afterwards plenty of water.

Most important symptoms and

effects

Difficulty in breathing. May cause central nervous system depression: Inhalation of high

vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea

and vomiting

Notes to Physician

Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media

Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam.

Unsuitable Extinguishing Media

Water may be ineffective, Do not use a solid water stream as it may scatter and spread fire

Flash Point

-4 °C / 24.8 °F

Method -

CC (closed cup)

Autoignition Temperature

427 °C / 800.6 °F

Explosion Limits

Upper

11.5 vol %

Lower

2.0 vol %

Oxidizing Properties

Not oxidising

Sensitivity to Mechanical Impact

No information available

Sensitivity to Static Discharge

No information available

Specific Hazards Arising from the Chemical

Flammable. Risk of ignition. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.

Containers may explode when heated.

Hazardous Combustion Products

Carbon monoxide (CO). Carbon dioxide (CO2).

Protective Equipment and Precautions for Firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full

protective gear.

NFPA

6. Accidental release measures

Personal Precautions

Use personal protective equipment as required. Ensure adequate ventilation.

Environmental Precautions

Should not be released into the environment. See Section 12 for additional Ecological

Information.

Methods for Containment and Clean

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

7. Handling and storage

Handling

Ensure adequate ventilation. Wear personal protective equipment/face protection. Do not

get in eyes, on skin, or on clothing. Avoid ingestion and inhalation.

Health

Flammability

Instability

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Physical hazards

N/A

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Ethyl acetate

Revision Date 13-Oct-2023

Storage.

Flammables area. Keep away from heat, sparks and flame. Keep container tightly closed in

a dry and well-ventilated place. Incompatible Materials. Strong oxidizing agents. Strong

acids. Amines. Peroxides.

8. Exposure controls / personal protection

Exposure Guidelines

9. Physical and chemical properties

Physical State

Liquid

Appearance

Colorless

Odor

sweet

Odor Threshold

50 ppm

No information available

Melting Point/Range

-83.5 °C / -118.3 °F

Boiling Point/Range

75 - 78 °C / 167 - 172.4 °F

Flash Point

-4 °C / 24.8 °F

Method -

CC (closed cup)

Evaporation Rate

6.2

Flammability (solid,gas)

Not applicable

Flammability or explosive limits

Upper

11.5 vol %

Lower

2.0 vol %

Vapor Pressure

103 mbar @ 20°C

Vapor Density

3.04

Specific Gravity

0.902

Solubility

Slightly soluble in water

Partition coefficient; n-octanol/water

No data available

Autoignition Temperature

427 °C / 800.6 °F

Decomposition Temperature

No information available

Viscosity

0.45 cP @ 20 °C

Component ACGIH TLV OSHA PEL NIOSH Mexico OEL (TWA)

Ethyl acetate TWA: 400 ppm (Vacated) TWA: 400 ppm

(Vacated) TWA: 1400 mg/m

TWA: 400 ppm

TWA: 1400 mg/m

IDLH: 2000 ppm

TWA: 400 ppm

TWA: 1400 mg/m

TWA: 400 ppm

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration

NIOSH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures

Ensure adequate ventilation, especially in confined areas. Use explosion-proof

electrical/ventilating/lighting equipment. Ensure that eyewash stations and safety showers

are close to the workstation location.

Personal Protective Equipment

Eye/face Protection

Wear appropriate protective eyeglasses or chemical safety goggles as described by

OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard

EN166.

Skin and body protection

Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection

No protective equipment is needed under normal use conditions.

Hygiene Measures

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Handle in accordance with good industrial hygiene and safety practice.

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Ethyl acetate

Revision Date 13-Oct-2023

Molecular Formula

C4 H8 O2

Molecular Weight

88.11

Surface tension

24 mN/m @ 20°C

10. Stability and reactivity

Reactive Hazard

None known, based on information available

Stability

Stable under normal conditions.

Conditions to Avoid

Incompatible products. Keep away from open flames, hot surfaces and sources of ignition.

Incompatible Materials

Strong oxidizing agents, Strong acids, Amines, Peroxides

Hazardous Decomposition Products

Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization

Hazardous polymerization does not occur.

Hazardous Reactions

None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information

Component Information

Component LD50 Oral LD50 Dermal LC50 Inhalation

Ethyl acetate 10,200 mg/kg ( Rat ) > 20 mL/kg ( Rabbit )

> 18000 mg/kg ( Rabbit )

58 mg/l (rat; 8 h)

Toxicologically Synergistic

Products

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation

Irritating to eyes

Sensitization

No information available

Carcinogenicity

The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Ethyl acetate 141-78-6 Not listed Not listed Not listed Not listed Not listed

Mutagenic Effects

No information available

Reproductive Effects

No information available.

Developmental Effects

No information available.

Teratogenicity

No information available.

STOT - single exposure

Central nervous system (CNS)

STOT - repeated exposure

None known

Aspiration hazard

No information available

Symptoms / effects,both acute and

delayed

May cause central nervous system depression: Inhalation of high vapor concentrations may

cause symptoms like headache, dizziness, tiredness, nausea and vomiting

Endocrine Disruptor Information

No information available

Other Adverse Effects

The toxicological properties have not been fully investigated.

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Ethyl acetate

Revision Date 13-Oct-2023

12. Ecological information

Ecotoxicity

Do not empty into drains.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Ethyl acetate EC50 = 3300 mg/L/48h Fathead minnow: LC50: 230

mg/l/ 96h

Gold orfe: LC50: 270

mg/L/48h

EC50 = 1180 mg/L 5 min

EC50 = 1500 mg/L 15 min

EC50 = 5870 mg/L 15 min

EC50 = 7400 mg/L 2 h

EC50 = 717 mg/L/48h

Persistence and Degradability

Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation

No information available.

Mobility

Will likely be mobile in the environment due to its volatility.

Component log Pow

Ethyl acetate 0.73

13. Disposal considerations

Waste Disposal Methods

Chemical waste generators must determine whether a discarded chemical is classified as a

hazardous waste. Chemical waste generators must also consult local, regional, and

national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes

Ethyl acetate - 141-78-6 U112 -

14. Transport information

DOT

UN-No

UN1173

Proper Shipping Name

ETHYL ACETATE

Hazard Class

Packing Group

TDG

UN-No

UN1173

Proper Shipping Name

ETHYL ACETATE

Hazard Class

Packing Group

IATA

UN-No

UN1173

Proper Shipping Name

ETHYL ACETATE

Hazard Class

Packing Group

IMDG/IMO

UN-No

UN1173

Proper Shipping Name

ETHYL ACETATE

Hazard Class

Packing Group

15. Regulatory information

United States of America Inventory

Component CAS No TSCA TSCA Inventory notification -

Active-Inactive

TSCA - EPA Regulatory

Flags

Ethyl acetate 141-78-6 X ACTIVE -

Legend:

TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)

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X - Listed

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Ethyl acetate

Revision Date 13-Oct-2023

'-' - Not Listed

TSCA - Per 40 CFR 751, Regulation of Certain Chemical

Substances & Mixtures, Under TSCA Section 6(h) (PBT)

Not applicable

TSCA 12(b) - Notices of Export

Not applicable

International Inventories

Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea

(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL

Ethyl acetate 141-78-6 X - 205-500-4 X X X X X KE-00047

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313

Not applicable

SARA 311/312 Hazard Categories

See section 2 for more information

CWA (Clean Water Act)

Not applicable

Clean Air Act

Not applicable

OSHA - Occupational Safety and

Health Administration

Not applicable

CERCLA

This material, as supplied, contains one or more substances regulated as a hazardous

substance under the Comprehensive Environmental Response Compensation and Liability

Act (CERCLA) (40 CFR 302)

Component

Hazardous Substances RQs CERCLA EHS RQs

Ethyl acetate

5000 lb -

California Proposition 65

This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know

Regulations

Component

Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Ethyl acetate

X X X - X

U.S. Department of Transportation

Reportable Quantity (RQ): Y

DOT Marine Pollutant N

DOT Severe Marine Pollutant N

U.S. Department of Homeland

Security

This product does not contain any DHS chemicals.

Other International Regulations

Mexico - Grade

Serious risk, Grade 3

Authorisation/Restrictions according to EU REACH

Component CAS No REACH (1907/2006) - REACH (1907/2006) - REACH Regulation (EC

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Ethyl acetate

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Annex XIV - Substances

Subject to Authorization

Annex XVII - Restrictions

on Certain Dangerous

Substances

1907/2006) article 59 -

Candidate List of

Substances of Very High

Concern (SVHC)

Ethyl acetate 141-78-6 - Use restricted. See item

75.

(see link for restriction

details)

REACH links

https://echa.europa.eu/substances-restricted-under-reach

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic

Pollutant

Ozone Depletion

Potential

Restriction of

Hazardous

Substances (RoHS)

Ethyl acetate 141-78-6 Listed Not applicable Not applicable Not applicable

Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?

Not applicable

Other International Regulations

Component CAS No Seveso III Directive

(2012/18/EC) -

Qualifying Quantities

for Major Accident

Notification

Seveso III Directive

(2012/18/EC) -

Qualifying Quantities

for Safety Report

Requirements

Rotterdam

Convention (PIC)

Basel Convention

(Hazardous Waste)

Ethyl acetate 141-78-6 Not applicable Not applicable Not applicable Annex I - Y42

16. Other information

Prepared By

Regulatory Affairs

Thermo Fisher Scientific

Email: [email protected]

Creation Date

13-Oct-2009

Revision Date

13-Oct-2023

Print Date

13-Oct-2023

Revision Summary

This document has been updated to comply with the US OSHA HazCom 2012 Standard

replacing the current legislation under 29 CFR 1910.1200 to align with the Globally

Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer

The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the

date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,

transportation, disposal and release and is not to be considered a warranty or quality specification. The information

relates only to the specific material designated and may not be valid for such material used in combination with any other

materials or in any process, unless specified in the text

End of SDS

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